Research

My research interests lie at the intersection of human genetics and clinical AI. I aim to harmonize diverse data sources, from electronic health records to multi-omics, to understand the genetic basis of disease and advance patient care.

Clinical AI

How can we make AI useful, efficient, and safe enough for everyday patient care?

In prep.

A Living Benchmark for Information Retrieval from Electronic Health Records

Cahoon JL, Stanwyck CO, et al.

Building a benchmark to evaluate how well language models retrieve information from electronic health records and reason across a patient's longitudinal history.

Publications & preprints

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2026

Clinically Grounded Privacy Evaluation of Medical LMs

Accepted · EMNLP 2026

Ronaghi S, Tonekaboni S, Stempfle L, Utti V, Cahoon JL, Hendrix N, Vala A, Ghassemi M, Alsentzer E.

A framework for evaluating patient information leakage from medical language models under realistic clinical privacy threats.

2026

Clinical Note Bloat Reduction for Efficient LLM Use

In review

Cahoon JL, Stanwyck C, Aali A, Madding R, Sun E, Jiang Y, Dhanasekaran R, Alsentzer E.

TRACE removes templated and duplicated content from clinical notes to reduce language model costs while preserving information for downstream clinical tasks.

2025

Structured Prompts Improve Evaluation of Language Models

In submission

Aali A, Mohsin MA, Bikia V, Singhvi A, Gaus R, Bedi S, Cui H, Fuentes M, Unell A, Mai Y, Cahoon JL, Pfeffer M, Daneshjou R, Koyejo S, Alsentzer E, Potts C, Shah NH, Chaudhari AS.

Studying how structured prompting changes benchmark performance and model rankings, using a reproducible framework that integrates DSPy and HELM.

2023

Continuous Stress Monitoring for Healthcare Workers: Evaluating Generalizability Across Real-World Datasets

ACM-BCB

Cahoon JL, Garcia L.

Evaluating wearable-based stress detection across three datasets and comparing gradient boosting with other machine learning methods for continuous monitoring.

Human Genetics

How can advances in data collection and processing help us understand genetic disease?

In prep.

Impact of participant-, clinician-, and EHR-derived phenotyping on rare disease diagnosis: a mixed-methods study

Ungar RA, Cahoon JL, Reuter C, Carter J, Bonner D, Cho M, Montgomery SB, Alsentzer E, Halley M.

Investigating how phenotyping from participants, clinicians, and electronic health records affects rare disease diagnosis.

Publications

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2025

A likelihood-based framework for demographic inference from genealogical trees

Nature Genetics

Fan C, Cahoon JL, Dinh BL, Vecchyo DO, Huber C, Edge MD, Mancuso N, Chiang CWK.

Inferring population demographic history from genealogical trees through a likelihood-based framework.

2024

Imputation Accuracy Across Global Human Populations

American Journal of Human Genetics

Cahoon JL, Rui X, Tang E, Simons C, Langie J, Chen M, Lo YC, Chiang CWK.

Characterizing imputation accuracy across ancestrally diverse populations and improving recovery of population-specific variants through meta-imputation.

2022

Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing

Human Genetics and Genomics Advances

Sheng X, Xia L, Cahoon JL, Conti DV, Haiman CA, Kachuri L, Chiang CWK.

Identifying and correcting strand errors in inverted genomic regions during coordinate conversion, including palindromic variants, to improve imputation and association testing.

Other Projects

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Additional work in immunology, machine learning, and computing for social good.

2025

Impact of Sanctuary Policies on Healthcare Utilization Among U.S. Agricultural Workers: A Causal Inference Approach

Course project

Jordan Cahoon. Outcomes Analysis, Stanford University.

Applying causal inference to study the relationship between sanctuary policies and healthcare utilization among agricultural workers.

2022–23

Deep Learning for Cancer Diagnosis from Digital Pathology

Research internship

Jordan Cahoon. Ellison Institute for Transformative Medicine.

Developing models for breast and prostate cancer diagnosis and refining a cloud-based quality control pipeline for whole slide images.

2022

Improving Large Language Models for Code-Switch Language

Course project

Jordan Cahoon. CSCI 499, University of Southern California.

Evaluating multilingual language models on Spanglish and comparing fine-tuning on code-switched and monolingual data.

2022

Predicting Foster Care Outcomes in the United States with the National Youth in Transition Database

Course project

Jordan Cahoon. CSCI 461, University of Southern California.

Analyzing predictors of substance abuse referrals for young people aging out of the U.S. foster care system.

2022

Computational Agroecology: Reinforcement Learning for Polyculture Design

CAIS++ project

Jordan Cahoon, et al. University of Southern California.

Developing a reinforcement learning agent to select and place crops in polycultures for improved sustainability and yield.

2021

PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection

Journal of Experimental Medicine

Oyesola OO, et al.

Analyzing single-cell RNA sequencing data to characterize how the PGD2–CRTH2 pathway regulates intestinal epithelial responses during helminth infection.

2021

Malaria Prediction with Weather Features

Project X

Jordan Cahoon, et al. University of Toronto Project X.

Using climate and outbreak data to predict malaria outbreaks in regions with sparse surveillance records.

2019

CRISPR-Cas9 Delivery in Chlamydomonas reinhardtii

Research internship

Jordan Cahoon. Baliga Lab, Institute for Systems Biology.

Developing an electroporation protocol for CRISPR-Cas9 delivery and investigating lipid production under nitrogen starvation.